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Eating less and moving more are the basics of weight loss that lasts. For some people, prescription weight loss drugs may help.

You’ll still need to focus on diet and exercise while taking these drugs, and they’re not for everyone.

Doctors usually prescribe them only if your BMI is 30 or higher, or if it’s at least 27 and you have a condition that may be related to your weight, like type 2 diabetes or high blood pressure.

The medication semaglutide (Wegovy) received FDA approval for treatment of obesity in 2021. More common prescription weight loss drugs which have been in use longer include: liraglutide (Saxenda), naltrexone-bupropion (Contrave), orlistat (Alli, Xenical), phentermine (Adipex-P, Ionamin, Pro-Fast), and phentermine-topiramate (Qsymia).

Before you get a  drug prescription, tell your doctor about your medical history. That includes any allergies or other conditions you have; medicines or supplements you take (even if they’re herbal or natural); and whether you’re pregnant, breastfeeding, or planning to get pregnant soon

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